Oxymercuration: Markovnikov Hydration of Alkenes

College Depth 171 in the knowledge graph I know this Set as goal
Unlocks 3 downstream topics
oxymercuration hydration markovnikov mercurinium-ion

Core Idea

Oxymercuration uses Hg(OAc)₂ to add water to alkenes in a Markovnikov fashion, with subsequent NaBH₄ reduction converting the C-HgOAc intermediate to C-H. The reaction proceeds via a mercurinium ion intermediate that is attacked by water, followed by carbocation rearrangement if needed. This method avoids carbocation rearrangement better than simple acid-catalyzed hydration.

Explainer

You already know that electrophilic addition to alkenes follows a general pattern: an electrophile attacks the electron-rich pi bond, forming a cationic intermediate, and then a nucleophile completes the addition. You also know from Markovnikov's rule that in unsymmetrical alkenes, the nucleophile ends up on the more substituted carbon. The challenge with simple acid-catalyzed hydration (adding H₃O⁺ to an alkene) is that it forms a true carbocation intermediate — and carbocations rearrange. If you have a substrate where the carbon skeleton could shift to form a more stable cation, you may get a product with a completely different connectivity than you intended. Oxymercuration solves this problem elegantly.

In the first step, mercury(II) acetate — Hg(OAc)₂ — acts as the electrophile. The mercury ion attacks the alkene's pi bond, but instead of forming an open carbocation, it forms a mercurinium ion: a three-membered ring where mercury bridges both carbons. This bridged intermediate is the key to the entire reaction's usefulness. Because the positive charge is delocalized across the mercury bridge rather than sitting on a single carbon, the intermediate never becomes a true carbocation. No rearrangement occurs, even on substrates that would rearrange instantly under acid-catalyzed conditions.

Water then attacks the mercurinium ion as a nucleophile. It preferentially attacks the more substituted carbon of the three-membered ring — this is the Markovnikov selectivity you expect. The more substituted carbon bears more of the positive character because it can better stabilize partial positive charge, making it the preferred site for nucleophilic attack. After deprotonation, you have an alcohol on the more substituted carbon and a mercury-containing group on the less substituted carbon.

The second step is demercuration: sodium borohydride (NaBH₄) replaces the C–HgOAc bond with a C–H bond. The mechanism of this reduction is complex (and likely involves radicals), but the practical result is clean: you get the Markovnikov alcohol product without rearrangement, without harsh acid conditions, and with excellent regioselectivity. This makes oxymercuration-demercuration the go-to method when you need Markovnikov hydration of an alkene and cannot tolerate the rearrangements that plague acid-catalyzed routes.

Practice Questions 5 questions

Prerequisite Chain

Counting to 10Counting to 20Understanding ZeroThe Number ZeroCounting to FiveOne-to-One CorrespondenceCombining Small Groups Within 5Addition Within 10Addition Within 20Two-Digit Addition Without RegroupingTwo-Digit Addition with RegroupingAddition Within 100Repeated Addition as MultiplicationMultiplication Facts Within 100Division as Equal SharingDivision as Grouping (Measurement Division)Division: Grouping (Repeated Subtraction) ModelDivision: Fair Sharing ModelDivision as Equal SharingDivision as GroupingBasic Division FactsDivision Facts Within 100Two-Digit by One-Digit DivisionDivision with RemaindersRemainders and Quotients in DivisionDivision Word ProblemsIntroduction to Long DivisionFactors and MultiplesPrime and Composite NumbersEquivalent FractionsRelating Fractions and DecimalsDecimal Place ValueReading and Writing DecimalsComparing and Ordering DecimalsAdding and Subtracting DecimalsMultiplying DecimalsDividing DecimalsDividing FractionsMixed Number ArithmeticOrder of OperationsInteger Order of OperationsVariable ExpressionsCombining Like TermsOne-Step EquationsTwo-Step EquationsSolving Multi-Step EquationsEquations with Variables on Both SidesAngle Pairs: Complementary, Supplementary, and VerticalParallel Lines and TransversalsCorresponding AnglesAlternate Interior AnglesTriangle Angle Sum TheoremExterior Angle TheoremTriangle Inequality TheoremSimilar Triangles: AA SimilaritySimilar Triangles: SSS and SAS SimilarityProportions in Similar TrianglesRight Triangle Trigonometry IntroductionTrigonometric Ratios ReviewRadian MeasureConverting Between Degrees and RadiansThe Unit CircleGraphing Sine and CosineGraphing Tangent and Reciprocal Trigonometric FunctionsDerivatives of Trigonometric FunctionsAntiderivativesIterated Integrals and Fubini's TheoremDouble Integrals in Cartesian CoordinatesDouble Integrals over Rectangular RegionsDouble Integrals in Polar CoordinatesDouble Integrals: Definition and SetupIterated Integrals and Fubini's TheoremDouble Integrals over Rectangular RegionsDouble Integrals over General RegionsApplications of Double Integrals: Area, Mass, and MomentsTriple Integrals in Cartesian CoordinatesTriple Integrals in Cylindrical and Spherical CoordinatesChange of Variables and the Jacobian DeterminantApplications of Triple Integrals: Volume and MassVector Fields and Their RepresentationsLine Integrals of Vector FieldsGreen's TheoremSurface Integrals and Flux of Vector FieldsSurface Integrals and Flux of Vector FieldsDivergence Theorem: Flux and OutflowDivergence TheoremElectric FluxGauss's LawConductors in Electrostatic EquilibriumCapacitance and CapacitorsDielectricsDielectric Constant and Relative PermittivityElectric Field Inside Dielectric MaterialsDielectric Materials and PolarizationDielectric Susceptibility and PermittivityEnergy Density in Electric FieldsElectric Current and Current DensityElectrical Resistance and ResistivityOhm's Law and Circuit ElementsElectromotive Force (EMF) and BatteriesKirchhoff's Circuit Laws: Voltage and CurrentDC Circuit Network Analysis MethodsTransient Response in RC CircuitsRC CircuitsLC and RLC CircuitsAC Circuits: FundamentalsImpedance and ReactanceAC Power and ResonanceElectromagnetic WavesThe Electromagnetic SpectrumBlackbody Radiation and Planck's LawPhotoelectric EffectThe Photon: Light as QuantaCompton ScatteringWave-Particle Dualityde Broglie WavelengthHeisenberg Uncertainty PrincipleWavefunction and the Born RuleThe Schrödinger EquationState Vectors and WavefunctionsQuantum SuperpositionQuantum EntanglementBell Theorem and Bell InequalitiesPostulates of Quantum MechanicsScattering TheoryIntroduction to Scattering TheoryPartial Wave Analysis in ScatteringSpin Angular MomentumElectron Spin and Intrinsic Magnetic MomentStern-Gerlach Experiment: Spin Quantization and MeasurementElectron Diffraction and Matter Wave PropertiesDavisson-Germer Experiment: Crystal Diffraction of ElectronsElectron Diffraction and Matter Wave InterferenceWavefunctions and Probability Density InterpretationQuantum Superposition and Linear Combinations of StatesQuantum Operators and ObservablesCanonical Commutation Relations and UncertaintyHeisenberg Uncertainty Principle and Measurement LimitsTime-Independent Schrödinger Equation and EigenvaluesHydrogen Atom in Quantum MechanicsSpectral Lines and Energy TransitionsSelection Rules for Atomic TransitionsLS and jj Coupling Schemes in Multi-Electron AtomsPauli Exclusion Principle and Antisymmetric WavefunctionsElectron Configuration and the Aufbau PrincipleThe Periodic Table and Atomic Electronic StructureThe Periodic TableElectron ConfigurationPeriodic TrendsIonization EnergyIonic BondingLewis StructuresResonance Structures and Delocalized ElectronsResonance and Formal ChargeMolecular Polarity and Dipole MomentsIntermolecular ForcesStates of Matter and Phase Changes: Melting, Boiling, and SublimationGas Laws and the Ideal Gas EquationGas Stoichiometry and Volume-Volume CalculationsThermochemistry and EnthalpyHeat Capacity and CalorimetryEntropy and Molecular DisorderSpontaneity and ΔGEntropy and Gibbs Free EnergyChemical EquilibriumAcid-Base ChemistryOrganic Reaction Mechanisms and Arrow PushingSN2 Substitution ReactionsSN1 Substitution ReactionsCarbocation Stability and RearrangementsMarkovnikov's Rule and Regioselectivity in Addition ReactionsOxymercuration: Markovnikov Hydration of Alkenes

Longest path: 172 steps · 757 total prerequisite topics

Prerequisites (2)

Leads To (1)